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Antihistamines include older antihistamines, also called first-generation antihistamines, and newer second-generation antihistamines.

First-generation antihistamines most of these antihistamines are available without a prescription, such as diphenhydramine (Benadryl), clemastine (Tavist), and chlorpheniramine (Chlor-Trimeton Allergy). These older antihistamines are more likely to cause drowsiness. Depe…